structural molecular biology

With the development and application of the new technologies, such as molecular biology, structural biology and protein engineering, many progresses have been made in the research of structures and functions of xylanase.

随着分子生物学、结构生物学的发展及蛋白质工程的应用，对木聚糖酶结构和功能的研究不断深入。

With the development of molecular biology and structural biology, the interaction energy between organic molecules and biological macromolecules has been understood profoundly. The optimization model has been developed from lock and key-based rigid one to induced-fit-based flexible one.

随着分子生物学和结构生物学的发展，人们对生理活性分子与生物大分子的相互作用有了更加深刻的认识，从基于锁钥原理的全刚性模型逐渐发展成为基于诱导契合的柔性模型。

Global minimization methods and their applications to structural molecular biology have made significant progresses in recent years.

全局极小化方法及其在结构生物学中的应用近年来取得了显著的进展。

In contrast to TOS, diversity-oriented organic synthesis ( DOS), aiming for creation of molecular structural diversity, is emerging as a frontier research direction in recent years. It closely associates with research in chemical biology or chemical genetics.

与之相对应，多样性导向合成是以产生分子结构多样性为目的，是近年发展起来的一个前沿研究方向，与化学生物学或化学基因组学的研究有密切的关系。

The construction of receptor structure based on the molecular biology and structural biology of α_1-AR and rational design on α_1-AR antagonists are introduced. And the further application of this method is also prospected.

介绍了基于α1-AR受体分子生物学与结构生物学的受体结构构建及其拮抗剂的设计，并对该技术的发展进行了展望。